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Abbreviations

6MWT = 6-minute walk test
ADL = activities of daily living
AE = adverse events
AL = amyloid light-chain
ASNC = American Society of Nuclear Cardiology
ATTR = transthyretin amyloidosis
ATTR-ACT = transthyretin amyloid cardiomyopathy clinical trial
ATTR-CM = transthyretin amyloid cardiomyopathy
ATTR-PN = transthyretin amyloid polyneuropathy
AUC = area under curve
CI = confidence interval
CMAD = cardiac mechanical assist device
Cmax = peak plasma concentration
CMR = cardiac magnetic resonance imaging
CTS= carpal tunnel syndrome
CV = cardiovascular
DPN = diabetic polyneuropathy
EE = efficacy-evaluable
EMB = endomyocardial biopsy
eGFR = estimated glomerular filtration rate
FDA= United States, Food and Drug Administration
GI = gastrointestinal
hATTR = Hereditary transthyretin amyloidosis
HF = heart failure
HFpEF = heart failure with preserved ejection fraction
HR = hazard ratio
IFE = immunofixation
ITT = intent-to-treat
KCCQ-OS = Kansas City Cardiomyopathy Questionnaire-Overall Summary
LS = least squares
LV = left ventricular
LVAD = left ventricular assist device
mBMI = modified body mass index
MOA = mechanism of action
MOD = mechanism of disease
NIS = Neuropathy Impairment Score
NIS-LL = Neuropathy Impairment Score-Lower Limbs
NSAID = nonsteroidal anti-inflammatory drug
NT-proBNP = N-terminal pro-B-type natriuretic peptide
Σ7 NTs nds = summated seven nerve tests normal deviate score
Σ3 NTSF nds = summated three nerve test small-fiber normal deviate score
NYHA = New York Heart Association
PYP = pyrophosphate
QOL = quality of life
QOL-DN = Quality of Life-Diabetic Neuropathy
SE=standard error
SPECT = single-photon emission computed tomography
SPEP = serumprotein electrophoresis
99mTc-DPD = 99mtechnetium-labeled 3,3-diphosphono-1,2-propanodicarboxylic acid
99mTc-HMDP = 99mtechnetium-labeled hydroxymethylene diphosphonate
99mTc-PYP = 99mtechnetium-labeled pyrophosphate
TQOL = total quality of life
TTR = transthyretin
UPEP = urine protein electrophoresis
wtATTR = Wild-type transthyretin amyloidosis