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ATTR-CM – a disease that may be present in patients with heart failure6,7
ATTR-CM – a fatal, underdiagnosed type of cardiomyopathy caused by aggregated misfolded proteins, called amyloid fibrils, that accumulate in the myocardium.
>> Subtypes of ATTR-CM6,8:
  • Wild-type ATTR (wtATTR)
  • Hereditary ATTR (hATTR)

>> ATTR-CM is frequently misdiagnosed, and delayed diagnosis can lead to significant clinical consequences for patients.9

>> Patients present with symptoms of heart failure and may also present with other manifestations, such as atrial fibrillation and carpal tunnel syndrome, often bilateral.7,9

>> Once diagnosed, untreated patients have a median survival of ≈3.5 years.9

In 2 studies,

wtATTR deposits were identified in the hearts of 10.2% - 13.3% of older patients with HFpEF10,11

Study descriptions10,11

>> Wild-type transthyretin amyloidosis as a cause of heart failure with preserved ejection fraction

The study by González-López et al. was a prospective, cross-sectional, single-center study at a tertiary university hospital in Madrid, Spain, to determine the prevalence of wtATTR-CM among elderly patients admitted to the hospital due to HFpEF. The study prospectively screened all patients ≥60 years of age admitted for HFpEF. The study population included 120 HFpEF patients (59% women, mean age: 82±8 years) with LV ejection fraction ≥50% and LV hypertrophy ≥12 mm. All eligible patients were offered a DPD scintigraphy scan to confirm transthyretin amyloid cardiomyopathy.

>> Endomyocardial Biopsy Characterization of HFpEF and Prevalence of Cardiac Amyloidosis

A prospective analysis in 108 patients (61% women, age range: 57-74 years) seen at the John Hopkins HFpEF Clinic who underwent endomyocardial biopsy to evaluate myocardial tissue histopathology.