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MOA / MOD

The mechanism of ATTR6,7

Amyloidogenic TTR cascade

TTR
Secreted as a tetramer
TTR
dissociation
The tetramer breaks into monomers
Amyloid fibril
formation
Misfolded monomers aggregate into amyloid fibrils
Deposition of
fibrils
Amyloid fibrils accumulate in different parts of the body, such as the nerves

VyndamaxTM is a selective stabilizer of TTR6,7

Amyloidogenic TTR cascade


TTR
Tafamidis binds to TTR at the thyroxine-binding sites, stabilizing the tetramer