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MOA / MOD


The mechanism of ATTR12,13

Amyloidogenic TTR cascade


TTR
Secreted as a tetramer

TTR
dissociation
The tetramer breaks into monomers

Amyloid fibril
formation
Misfolded monomers aggregate into amyloid fibrils

Deposition of
fibrils
Amyloid fibrils accumulate in different parts of the body, such as the nerves

VyndamaxTM is a selective stabilizer of TTR12,13

Amyloidogenic TTR cascade


TTR
Tafamidis binds to TTR at the thyroxine-binding sites, stabilizing the tetramer